Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor
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چکیده
منابع مشابه
Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor
The successful genetic engineering of patient T cells with γ-retroviral vectors expressing chimeric antigen receptors or T-cell receptors for phase II clinical trials and beyond requires the large-scale manufacture of high-titer vector stocks. The production of retroviral vectors from stable packaging cell lines using roller bottles or 10- to 40-layer cell factories is limited by a narrow harve...
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ژورنال
عنوان ژورنال: Journal of Immunotherapy
سال: 2015
ISSN: 1524-9557
DOI: 10.1097/cji.0000000000000072